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. 2024 Apr 8;25(7):4117. doi: 10.3390/ijms25074117

Figure 1.

Figure 1

Association of M2-defining macrophage gene expression with histologic subtype and pTMN stage. (A) Histologic subtypes for intestinal adenocarcinomas, diffuse adenocarcinoma, mucinous adenocarcinoma, and signet ring cell adenocarcinoma are associated with M2-defining signatures. One-way ANOVA, p < 0.001. (B) Within each histologic subtype, M2-defining macrophage signature expression is significantly greater than both M1-defining and T-cell cytolytic signature expression. t-test for each comparison, * p < 0.05. (C) Greater M2-defining macrophage expression is associated with more advanced stages. t-test, p = 0.02. M2TS, M2 transcriptomic signature. NOS type, not otherwise specified type. TNM, tumor node metastasis. M1TS, M1 transcriptomic signature. CTLTS, cytotoxic T-lymphocyte transcriptomic signature.