Table 2.
Univariate Cox regression analysis of survival in the peritoneal fluid cohort.
| Patients (%) | HR (95% CI, p-Value) | ||
|---|---|---|---|
| M2TS Expression | Low | 15 (53.6) | ref |
| High | 13 (46.4) | 3.14 (1.17–8.46, 0.02) | |
| Age (years) | ≤40 | 7 (25.0) | ref |
| >40 and ≤65 | 12 (42.9) | 3.67 (0.79–17.05, 0.097) | |
| >65 | 9 (32.1) | 2.51 (0.50–12.53, 0.26) | |
| Age (years) | Mean ± SD | 55.9 ± 17.7 | 1.01 (0.99–1.04, 0.33) |
| Gender | Female | 13 (48.1) | ref |
| Male | 14 (51.9) | 0.96 (0.36–2.57, 0.93) | |
| Ethnicity | Asian | 9 (32.1) | ref |
| Black | 1 (3.6) | 3.21 (0.35–29.23, 0.30) | |
| Hispanic | 9 (32.1) | 0.93 (0.25–3.49, 0.92) | |
| Non-Hispanic White | 8 (28.6) | 1.76 (0.53–5.79, 0.35) | |
| Other | 1 (3.6) | 0.00 (0.00–Inf, 1.0) | |
| Resection | No | 17 (60.7) | ref |
| Yes | 11 (39.3) | 2.31 (0.89–6.02, 0.09) | |
| Stage | I-III | 4 (14.3) | ref |
| IV | 24 (85.7) | 5.53 (0.69–44.07, 0.106) | |
| Lauren Classification | Diffuse | 21 (75.0) | ref |
| Intestinal | 7 (25.0) | 1.53 (0.56–4.18, 0.40) | |
| Differentiation | Moderately | 2 (7.1) | ref |
| Poorly | 25 (89.3) | 0.23 (0.05–1.09, 0.06) | |
| Well to moderately | 1 (3.6) | NA | |
| Microsatellite Status | MSS | 24 (85.7) | ref |
| MSI high | 1 (3.6) | 15.04 (1.34–169.06, 0.028) | |
| Unknown | 3 (10.7) | 2.36 (0.66–8.50, 0.19) |
HR, hazard ratio. CI, confidence interval. M2TS, M2 transcriptional signature. Ref, reference value. SD, standard deviation. MSS, microsatellite stable. MSI, microsatellite instable. Bolded p-value indicates statistical significance (p < 0.05).