Figure 4.
REV1 activity on Hoogsteen-blocking 7-deazaA (A) and Watson–Crick-blocking εA (B) lesions. Primer extension reactions were carried out in the presence of the wild-type REV1 and all four dNTPs (N) or individual nucleotide substrates (A—dATP, G—dGTP, T—dTTP and C—dCTP); “–”—control reactions without dNTPs. The mean values of primer extension and standard errors are indicated; p-values < 0.05 are shown by *.
