Figure 6.

Linking pre-diagnosis diet to treatment outcomes through fecal microbiota. Our study revealed multiple links between pre-diagnosis diet, microbes, and patient outcomes, which are summarized in this figure. Mature and vegetarian diets and rMED score were positively associated with baseline microbial diversity, while pre-packaged diet was negatively associated with six-month diversity. Increased baseline diversity was associated with prolonged survival until disease flare. A decreased pre-packaged diet adherence and increased meat diet adherence were associated with decreased time until disease flare and lack of EEN response, respectively. Finally, increased rMED score was associated with a worse six-month PGA and a decreased likelihood for PGA improvement from baseline.