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Partial Nrf2 ablation increases the expression of senescence markers in peripheral tissues. Analysis of Cdkn2a (p16INK4a) gene expression in the liver (A) and epididymal white adipose tissue (eWAT) (B) samples from Nrf2+/+ and Nrf2+/− mice after 20 weeks of consuming a standard diet (SD) or high fat diet (HFD) (n = 3−6/group). Data are presented as mean ± SEM. * indicates a significant difference (p < 0.05) from the indicated group.
