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. Author manuscript; available in PMC: 2024 Apr 12.
Published in final edited form as: Cell Rep. 2024 Mar 7;43(3):113904. doi: 10.1016/j.celrep.2024.113904

Figure 5. The Slack-R455H mutation upregulates NaV channel subunit expression.

Figure 5.

(A) Representative western blotting and quantitative analysis of protein levels of NaV1.1, NaV1.2, and NaV1.6 in cultured cortical neurons on DIV 14 obtained from WT, Slack+/R455H, and SlackR455H/R455H littermates. Data are shown as mean ± SEM (n = 4 cultures, 1-way ANOVA).

(B) Representative western blotting and quantitative analysis of protein levels of NaV1.1, NaV1.2, and NaV1.6 in cerebral cortex of 2-month-old WT and Slack+/R455H mice. Data are shown as mean ± SEM (n = 4 mice, Student’s t test). *p < 0.05.