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. 2024 Feb 21;52(6):3358–3374. doi: 10.1093/nar/gkae094

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© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Predicted TDMD-like site architectures within circRNAs are more frequent for the most highly paired miRNAs. (A) Examples of predicted TDMD-like sites within circRNAs using scanMiR. All five miRNAs belong to the ‘+++ paired’ quartile. (B) Pie charts showing the proportion of predicted linear RNA- and circRNA–miRNA interactions involving at least one predicted TDMD-like site against miRNAs within quartiles of increasing miRNA-specific Pairing coefficient. 5′UTRs, CDSs and 3′UTRs within linear RNAs of protein-coding genes were considered for this analysis. Shown are the p-values for the Fisher's Exact test between each quartile and the least paired quartile (‘- paired’).