Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 14;52(6):3106–3120. doi: 10.1093/nar/gkae095

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — Emerging different chromatin profiles among single cells when entering the dome stage. (A) UMAP visualisation of nucleus from the 4.1 hpf (sphere-dome) and the 4.3 hpf (dome) stages coloured by different clusters. Cluster annotations were indicated on the UMAP plot. A schematic view of the structure of the embryo was also shown at the top left. (B) The same UMAP plot as in (A), coloured by the normalised reads from the indicated gene locus. (C) Genome browser tracks showing the aggregated single-nucleus ATAC-seq signal from indicated cell clusters. Five examples were shown around the mark genes of EVL and YSL cells. (D) Diffusion pseudotime analysis of the nuclei from the 4.1 hpf (sphere-dome) and the 4.3 hpf (dome) stages, coloured by the pseudotime (left) or cell identity (right). (E) Heatmap representation of gene activity changes along three different branches. Important marker genes for EVL and YSL cells were indicated.