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[Preprint]. 2024 Apr 1:2024.03.31.587467. [Version 1] doi: 10.1101/2024.03.31.587467

Figure 6. CAR activation induces CD40L expression in Tregs.

Figure 6.

(A) CD40L and TIGIT surface expression on No Act Tregs, TCR Tregs, and CAR Tregs 48h post-activation. Representative histograms on the left and summary data on the right. (B) CD40L and TIGIT surface expression on No Act Tregs, TCR Tregs, and CAR Tregs one-week post-activation. Representative histograms on the left and summary data on the right. (C) Expression of selected genes in CAR Tregs and TCR Tregs 24h post-activation, evaluated by qPCR. Values represent technical replicates of representative experiments. Bars represent mean ± SD. For Figures 6A and 6B, one-way ANOVA test with Tukey’s multiple comparison correction. For Figure 6C, unpaired Student’s t test. ****, p < 0.0001; ***, p < 0.001; **, p < 0.01; *, p < 0.05; ns, not significant.