Figure 3. Transduction with IRF8 in vivo suppresses the growth of intracerebral SB28 tumors.

(A) Schematic of in vivo studies. SB28 cells pre-transduced at 2% with either RRV-EMPTY or RRV-IRF8 were implanted intracerebrally. Tumor growth kinetics were monitored using bioluminescence (BLI) twice per week until study completion. Tissues were harvested and dissociated into single cells for analysis. (B) Kaplan-Meier curves showing survival; SB28 WT, SB28 RRV-EMPTY, and SB28 RRV-IRF8, (C) BLI imaging data corresponding with tumor growth kinetics. P-values assessed on day 12 post-tumor inoculation.