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Comparison of the amino acid sequences of the pre-S domains of DHBV (subtype 16, upper row) and HHBV (subtype 4, lower row). Amino acid positions are indicated by numbers beside the rows. Conserved amino acids are boxed. Insertions within the HHBV pre-S sequence are shown in brackets. The minimal competitor region representing the receptor binding domain (aa 30 to 115) is indicated by the bar at the top of the DHBV pre-S sequence.
