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. 2024 Feb 29;134(8):e174051. doi: 10.1172/JCI174051

Figure 2. G-MDSCs infiltrating S. aureus PJI are characterized by strong glycolytic and hypoxia transcriptional signatures.

Figure 2

(A) Expression of glycolytic and PPP genes in G-MDSC and PMN clusters identified by scRNA-Seq analysis. (B) Pathway analysis of differential expression data depicting glycolysis, hypoxia response, and PPP in G-MDSCs versus PMNs. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, correlation-weighted Kolmogorov-Smirnov with Benjamini-Hochberg correction. (C) Metabolic modeling by COMPASS using scRNA-Seq expression data in G-MDSCs and PMNs with (D) specific pathways noted. (E) Identification of glycolytic and PPP genes and their relationship to predicted pathogenicity metabolic scores in G-MDSCs and PMNs.