Figure 8. Mrp8Hif1a conditional KO mice exhibit improved infection outcomes.
Mrp8NullHif1afl/fl and Mrp8CreHif1afl/fl mice were infected with S. aureus, whereupon (A) bacterial burden in the tissue, joint, femur, and on the implant and (B) immune infiltrates in the soft tissue surrounding the infected joint were assessed at days 7 (n = 11 for Mrp8NullHif1afl/fl; n = 14 for Mrp8CreHif1afl/fl) and 14 (n = 12/group) after infection. Data are represented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001, unpaired 2-tailed t test.