Table 1.

Participant characteristics

	HC			IBS			GLM p-values
	Male	Female	Sex diff p-value	Male	Female	Sex diff p-value	Dx	Sex	Dx*Sex
N	66	104		62	170
Hispanic (%) †	28.8	37.5	0.32	14.5	24.3	0.11	0.006	0.12
Race (%) †‡			0.22			0.71	0.01	0.58
Asian	19.7	28.8		25.8	21.4
Black	6.1	8.7		6.5	7.5
White	51.5	33.7		58.1	54.3
Mixed	10.6	10.6		6.5	8.7
Other	12.1	18.3		3.2	8.1		0.06	0.76
Age (yrs)	30.1±1.3	31.0±1.0	0.55	31.2±1.3	27.7±0.8	0.02	0.33	0.26	0.04
ACE (0–10)	0.9±0.2	1.4±0.2	0.06	1.7±0.2	1.8±0.1	0.72	0.006	0.10	0.26
HAD-Anxiety (0–21)	3.4±0.5	4.2±0.4	0.19	7.6±0.5	7.7±0.3	0.86	<0.001	0.29	0.41
HAD-Depression (0–21)	1.7±0.4	1.8±0.3	0.88	3.8±0.4	3.3±0.2	0.17	<0.001	0.41	0.29
Bowel Habit (C:D:U:M)				8:40:7:7	68:47:13:45	<0.001
IBS-SSS (0–500)				195.6±11.4	230.1±6.8	0.01
IBS-QOL (0–100)				72.4±2.7a	63.2±1.6b	0.004

Data are presented as mean±standard error, unless otherwise indicated. Range of scores on questionnaires is indicated in parentheses.

^†Fisher’s exact test

^‡(other includes American Indian, Hawaiian, and decline to state)

^an=58

^bn=167

HC, healthy control; IBS, irritable bowel syndrome; Dx, diagnosis; GLM, general linear modelling; ACE, Adverse Childhood Experiences; HAD, Hospital Anxiety and Depression scale; IBS-SSS, IBS Symptom Severity Scale; IBS-QOL, IBS-Quality of Life questionnaire; C:D:U:M, constipation, diarrhea, unspecified, mixed