Table 2. AbbVie Rat Hepatotoxicity Predictive Model.

The performance of a proprietary predictive model of rat hepatoxicity (3–5 day exposure) compared to a 2-week toxicity study in rats was evaluated using 52 compounds covering 16 different projects and naïve to the training set. Overall, the model demonstrated an excellent accuracy of 96% with a good positive predictive value (8 out of 9) and a good negative predictive value (42 out of 43). The prevalence of hepatotoxicity of 9/52 was overall consistent with institutional data at the time the model was generated.

Network in Short-Term Study		Positive	Negative
	Positive	8	1
	Negative	1	42
	Accuracy (96.2%)	Sensitivity (88.9%)	Specificity (97.7%)