Table 3.
Multivariate cox analysis for the patients stratified by AJCC stage.
| Variable | Stage I |
Stage II |
Stage III |
Stage IV |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age, 1 year increased | 1.05 | 1.04, 1.06 | <0.001 | 1.03 | 1.03, 1.04 | <0.001 | 1.02 | 1.02, 1.02 | <0.001 | 1.02 | 1.01, 1.02 | <0.001 |
| Gender (male vs female) | 1.23 | 1.07, 1.41 | 0.004 | 1.10 | 1.03, 1.18 | 0.005 | 1.11 | 1.06, 1.16 | <0.001 | 1.04 | 1.00, 1.08 | 0.046 |
| Sidedness (right vs left) | 0.75 | 0.65, 0.87 | <0.001 | 0.69 | 0.65, 0.74 | <0.001 | 1.10 | 1.05, 1.15 | <0.001 | 1.26 | 1.21, 1.31 | <0.001 |
| Size, 1 cm increased | 1.15 | 1.12, 1.19 | <0.001 | 1.07 | 1.06, 1.08 | <0.001 | 1.07 | 1.06, 1.08 | <0.001 | 1.03 | 1.02, 1.04 | <0.001 |
| Grade (poor/anaplastic vs high/moderate) | 1.10 | 0.86, 1.42 | 0.439 | 1.08 | 0.99, 1.19 | 0.095 | 1.51 | 1.44, 1.59 | <0.001 | 1.42 | 1.36, 1.48 | <0.001 |
| Histology | ||||||||||||
| Adenocarcinoma | 1 | Reference | – | 1 | Reference | – | 1 | Reference | – | 1 | Reference | – |
| Mucinous adenocarcinoma | 0.99 | 0.71, 1.37 | 0.951 | 1.07 | 0.96, 1.20 | 0.234 | 1.21 | 1.12, 1.30 | <0.001 | 1.09 | 1.02, 1.17 | 0.012 |
| Signet-ring cell adenocarcinoma | 0.51 | 0.07, 3.66 | 0.503 | 1.35 | 0.90, 2.03 | 0.150 | 2.18 | 1.92, 2.48 | <0.001 | 1.50 | 1.31, 1.71 | <0.001 |
AJCC = American Joint Committee on Cancer, CI = confidence interval, HR = hazard ratio.