Fig. 5.

Genes commonly altered between lenvatinib and FGFR inhibitor groups and lenvatinib-induced gene alterations in human HCC. a Venn figure for common up- and downregulated gene numbers between the lenvatinib and FGFR inhibitor groups (n = 3/group). b Gene ontology enrichment analysis of 161 commonly downregulated genes in the lenvatinib and FGFR inhibitor groups. C Restructured human RNA sequencing data using GSE214324 from the GEO database. Gene expression in MHCC-97H cells treated with various doses of lenvatinib (40, 60, 80, and 100 μM) compared to that in dimethyl sulfoxide-stimulated cells. FGFR fibroblast growth factor receptor, VT vehicle treatment, VEGFR vascular endothelial growth factor receptor, PPAR peroxisome proliferator-activated receptor