Fig. 4.

Inhibition of ACC destabilized info preference in female but not male rats, while latencies and the RR were unaltered by inhibition. A) Baseline info preference for females (top) and males (bottom) over two baselines. The first baseline (BL1) was obtained after surgery, and the second baseline (BL2) was obtained at the end of the experiment. B) Mean change in preference for the info alternative between the last three sessions of baseline after surgery minus the preference during VEH and CNO administration for females (top) and males (bottom). Note that a positive change indicates a shift in preference toward the info option, whereas a negative change indicates a preference shift toward the NoInfo option. Values around 0 indicate no change in preference. C) Total number of observations of latency to choose across drug conditions is shown for each trial type. Dashed lines indicate the median latency. A significant difference between trial types was found, where choice trials were faster than forced (Info and NoInfo) trials. D) Violin plots of the distribution of total RR during the 60 s cue presentations are presented for each cue for all drug conditions for females (left) and males (right). Dots indicate the median RR for each cue. Females responded more than males and a significant effect of cue was found. ^**P < 0.01, ^*P < 0.05.