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. 2024 Feb 12;130(8):1316–1323. doi: 10.1038/s41416-023-02569-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — In our analyses, intracranial progression-free survival from BM (brain metastasis) resection (BM-iPFS) was improved in case of low TMB (Tumor Mutation Burden) (<5.02 Mut/Mb) (a) and absence of HER2 amplification (HER2+) (b) on BM; on the contrary, no correlation was observed with KRAS status (c) or TILs (Tumor Infiltrating Lymphocytes) on BM (d).