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. 2024 Feb 27;25(4):1814–1834. doi: 10.1038/s44319-024-00098-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Panel (A, B) shows volcano plots of SG RNA compared to total RNA for WT (A) and NAT10 KO HeLa cells (B) from RNA sequencing experiments done in four biological replicates. Benjamini-Hochberg adjusted p-value. We compared enriched (C) and depleted (D) transcripts with previous studies purifying SG from U2OS cells (Matheny et al, 2021; Khong et al, 2017). We assessed translation efficiency (E) and mRNA length (F) for high-confidence SG transcripts enriched >2-fold in all studies and those enriched only in HeLa cells in the present study, respectively (n = 559 high-confidence transcripts, n = 915 transcripts unique in HeLa). Unpaired two-tailed Student’s t-test, ****p < 0.0001.