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. 2024 Apr 12;15:3194. doi: 10.1038/s41467-024-47401-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A UMAP visualisation of scored gene expression of COGs in piwi+ cells. B Expression heatmap of 200 top TFs expressed in piwi+ cells and their expression in the main broad cell types, showing several clusters of TFs expressed in both piwi+ cells and one or more broad types. C Expression plots of example TFs coexpressed in piwi+ cells and other broad types. D Limma differential gene expression analysis of piwi+ cells (clusters 1, 2 and 8) against all other cell types (bayesian t-statistics from the eBayes limma function, two-sided; adjusted p-values with Benjamini-Hochberg correction). Green colour indicates upregulated genes, red colour indicates downregulated genes. Light colour shade indicates above threshold of logFC, darker colour shade indicates above threshold of logFC and significant (adjusted p-value < 0.05). Examples listed are coloured in darker green. E Detail of annotated epigenetic regulators and their expression enriched in piwi+ cells, and example UMAP visualisations of representative epigenetic factors.