Table 1.
Summary of pathological changes and SARS-CoV-2 infection percentage in adult and elder COVID-19 NHPs and vaccinated-infected NHPs
| Groups (No.) Lesions (degree) | Control (6) | Rhesus macaque models of COVID-19 (15) | Inactivated vaccines/subunit (recombinant protein) vaccines + prototypic strain infection (35) | ||
|---|---|---|---|---|---|
| Adult (3) | Elder (3) | Adult-prototypic strain infection (9) | Elder-prototypic strain infection (6) | ||
| Degeneration of islets | 0/3 | 1/3 | 1/9 | 4/6 | 1/35 |
| Necrosis of islets | 0/3 | 0/3 | 0/9 | 3/6 | 0/35 |
| Telangiectasis in the islets | 0/3 | 1/3 | 1/9 | 1/6 | 3/35 |
| Atrophy of islets | 0/3 | 1/3 | 0/9 | 5/6 | 0/35 |
| Hyperplasia of islet cell | 0/3 | 0/3 | 0/9 | 1/6 | 0/35 |
| Islet amyloidosis | 0/3 | 1/3 | 0/9 | 4/6 | 0/35 |
| Degeneration of exocrine pancreas | 1/3 | 0/3 | 0/9 | 3/6 | 0/35 |
| Shedding cells in the pancreatic exocrine duct | 0/3 | 0/3 | 2/9 | 1/6 | 4/35 |
| Dilatation of pancreatic exocrine duct | 0/3 | 1/3 | 0/9 | 1/6 | 0/35 |
| Inflammatory cell infiltration | 0/3 | 1/3 | 4/9 | 4/6 | 8/35 |
Notes: The table summarizes the proportion of different lesions, percentage of inflammation in different groups