Reagent or resource	Source	Identifier
Antibodies
Anti-SARS spike glycoprotein antibody [1A9]	Abcam	Cat# ab273433
GeneTex:SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL5511]	GeneTex	Cat# GTX635689
SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL455-MS]	GeneTex	Cat# GTX635712
SARS-CoV-2 (COVID-19) Spike S1 antibody [HL6]	GeneTex	Cat# GTX635654
Anti-Ribonuclease 3/ECP antibody	Abcam	Cat# ab207429
Anti-Insulin antibody [EPR17359]	Abcam	Cat# ab181547
Glucagon Antibody	Cell Signaling Technology	Cat# 2760
Anti-Somatostatin 28 antibody [EPR3359(2)]	Abcam	Cat# ab111912
Anti-Pancreatic Polypeptide Antibody [EPR23320-10]	Abcam	Cat# ab272732
Anti-Insulin Receptor alpha antibody [EPR23962-157]	Abcam	Cat# ab283689
Anti-Insulin Receptor beta antibody [EPR23566-103]	Abcam	Cat# ab278100
Anti-Trypsin antibody [EPR19497]	Abcam	Cat# ab200996
Anti-ICA 512/PTPRN antibody [EPR20718]	Abcam	Cat# ab207750
Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker	Abcam	Cat# ab52625
Anti-ACE2 antibody	Abcam	Cat# ab15348
Anti-TMPRSS2 antibody [EPR3862]	Abcam	Cat# ab109131
Anti-Neuropilin 1 antibody [EPR3113]	Abcam	Cat# ab81321
CD54/ICAM-1 (E3Q9N) XP	Cell Signaling Technology	Cat# 67836 S
Anti-VCAM1antibody [EPR5047]	Abcam	Cat# ab134047
Cleaved Caspase-3 (Asp175) Antibody	Cell Signaling Technology	Cat# 9661
Anti-G3BP1 antibody	Cell Signaling Technology	Cat# 17798
Anti-alpha smooth muscle Actin antibody [SP171]	Abcam	Cat# ab150301
COL1A1 (E8F4L) XP® Rabbit mAb	Cell Signaling Technology	Cat# 72026
Anti-Ki67 antibody	Abcam	Cat# ab15580
Anti-CD31 antibody	Abcam	Cat# ab28364
Anti-Myeloperoxidase antibody [EPR20257]	Abcam	Cat# ab208670
Anti-CD4 antibody [UMAB64]	Zsbio	Cat# ZA-0519
Anti-CD20 antibody [EP459Y]	Abcam	Cat# ab78237
Anti-CD68 antibody [C68/684]	Abcam	Cat# ab201340
Critical commercial assays
Monkey Insulin ELISA Kit (Colorimetric)	NOVUS	Cat# NBP2-60076; RRID: C1482161422
Cynomolgus Monkey C-Peptide ELISA Kit (Colorimetric)	NOVUS	Cat# NBP2-59957; RRID: C1482031409
Amylase Assay Kit (Colorimetric)	Abcam	Cat# ab102523; RRID: 1010078-3
Monkey LIPF/GL/Gastric Lipase (Sandwich ELISA) ELISA Kit - LS-F45315	Lifespan	Cat# LS-F45315-1; RRID: 224374
Glucose Assay Kit (Colorimetric/Fluorometric)	NOVUS	Cat# KA0831
Monkey GAD65 (Sandwich ELISA) ELISA Kit - LS-F44382	Lifespan	Cat# LS-F44382-1; RRID: 224373
Monkey ICAM-1/CD54 ELISA Kit (Colorimetric)	NOVUS	Cat# NBP1-92712; RRID: 325366-005
Monkey Vascular Cell Adhesion Molecule 1 (VCAM1) ELISA Kit	Abbexa	Cat# abx153571; RRID: E2212721G
Porcine PPP1R1A / IPP1 (Sandwich ELISA) ELISA Kit - LS-F47439	Lifespan	Cat# LS-F47439-1; RRID: 224375
Bond Polymer Refine Detection	Leica Biosystems Newcastle Ltd.	Cat# DS9800-CN
Bond Wash Solution 10X Concentrate	Leica Biosystems Newcastle Ltd.	Cat# AR9590-CN
Bond Dewax Solution	Leica Biosystems Newcastle Ltd.	Cat# AR9222-CN
Bond Epitope Retrieval Solution 1	Leica Biosystems Newcastle Ltd.	Cat# AR9961-CN
Bond Epitope Retrieval Solution 2	Leica Biosystems Newcastle Ltd.	Cat# AR9640-CN
Bond Primary Antibody Diluent	Leica Biosystems Newcastle Ltd.	Cat# AR9352-CN
Bond Research Detection System	Leica Biosystems Newcastle Ltd.	Cat# DS9455
Bond Aspirating Probe Cleaning Kit	Leica Biosystems Newcastle Ltd.	Cat# CS9100
Bond Open Container 7 mL - 10 Pack	Leica Biosystems Newcastle Ltd.	Cat# OP79193
Bond Titration kit - 10 Pack	Leica Biosystems Newcastle Ltd.	Cat# OPT9049
Opal Polaris 7-Color Manual IHC Kit	Akoya Biosciences	Cat# NEL861001KT
OPAL 7-Color auomation IHC KIT 50 SLIDES	Akoya Biosciences	Cat# NEL821001KT
Opal Polaris 480 Reagent Pack	Akoya Biosciences	Cat# FP1500001KT
Opal Polaris 780 Reagent Pack	Akoya Biosciences	Cat# FP1501001KT
RNAscope Probe-V-nCoV2019-S	Advanced Cell Diagnostics	Cat# 848561
2.5HD DAB detection kit	Advanced Cell Diagnostics	Cat# 322300
Modified Masson’s Trichrome Stain Kit	Beijing Solarbio Science & Technology Co., Ltd.	Cat# G1346; RRID: 20220511
Congo Red Stain Kit	Abcam	Cat# ab150663; RRID: GR3330147-1
Eosinophil-Mast Cell Stain Kit	Abcam	Cat# ab150665
Software and algorithms
ImageJ 1.53c	NIH	https://imagej.nih.gov/ij/
GraphPad Prism 8.0	GraphPad Software	https://www.graphpad.com
HALO v3.0.311.262	Indica Labs	https://indicalab.com/halo/
PerkinElmer’s inForm® advanced image analysis software	PerkinElmer, Inc.	https://www.perkinelmer.com.cn/
Phenochart 1.1.0	PerkinElmer, Inc.	https://www.perkinelmer.com.cn/