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. 2024 Apr 12;15:3182. doi: 10.1038/s41467-024-47485-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Average repeat gain of non-induced RPE1-AAVS1-CAG115 cells with treatment of either branaplam (a) or risdiplam (b), with the color indicating the drug concentration. Each treatment group and timepoint had five cultures analyzed, except risdiplam day 0 which had three. c Drug cytotoxicity quantified by high-throughput image analysis of cells treated with DNA labeling of dead cells. d Average background autofluorescence pixel intensity. For c and d, 81 images were analyzed per treatment. Box plots show the 25th and 75th percentiles (box), median (horizontal line), and range (whiskers, which are capped at 1.5x the inter-quartile range). Source data are provided as a Source Data file.