Figure 2. Cutaneous, Subcutaneous, and Breast Angiosarcoma (N = 13 955).

A, US-reported incidence rate, 2001-2020. Error bars indicate 95% CIs. B, Breakdown by body site, sex, and first or second or later malignant neoplasm. C, Changes in incidence rate for breast angiosarcoma among women based on whether the angiosarcoma was the first reported malignant neoplasm or second or later reported malignant neoplasm. Error bars indicate 95% CIs. D, Percentage by site and sex that are the second or later malignant neoplasm for the patient. APC indicates annual percentage change.

^aP < .001.

^bP = .006.