Figure 1.

Main findings of the transcriptomics analysis

(A) Principal component analysis of transcripts found in RLS patients and controls showing the clustering f the two groups by using the first principal component (PC1) and the second (PC2).

(B) Heatmap of significant statistical differences of the mRNA expression profile found in RLS patients and controls.

(C) Volcano plot displays the distribution of differentially expressed transcripts by their fold change and p value. As also marked by the different colors, the most upregulated genes are toward the right, the most downregulated genes are toward the left, and the most statistically significant genes are on the top.