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. 2024 Apr 12;22:175. doi: 10.1186/s12951-024-02427-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — In vivo delivery of CrLNPs. A Scheme on the treatment of CrLNP_6.0 to HEK293T xenograft mouse model. CrLNP_6.0, including AF647-conjugated Cas9, was treated for fluorescence imaging. B IVIS imaging at different time points after intratumoral injection of CrLNP_6.0, and C quantification of signals (n = 3). Data are shown as mean ± SD, *P < 0.05, ****P < 0.0001 by student’s t-test. D Confocal microscopy of tumor tissues 72 h after injection of CrLNP_6.0. Scale bar, 40 μm. Flow cytometry of cells from tumor tissues 72 h after injection with CrLNP_6.0, shown by E scatter plot and F histogram of representative samples for each group, as well as G mean values for each group (n = 3). Data are shown as mean ± SD, *P < 0.05 by one-way ANOVA.