Fig. 6.

In vivo gene editing by treatment of CrLNP_6.0. A Scheme on the treatment of CrLNP_6.0 targeting the surrogate reporter to the HEK293T xenograft mouse model. B Confocal microscopy of tumor tissues 72 h after intratumoral injection of CrLNP_6.0. Scale bar, 40 μm. Gene editing efficiencies measured by flow cytometry of cells from tumor tissues 72 h after injection, shown as C scatter plot of a representative sample from each group, and D mean values for each group (n = 3). Data are shown as mean ± SD, *P < 0.05 by one-way ANOVA