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. 2024 Apr 12;22:156. doi: 10.1186/s12916-024-03383-2

Table 2.

Means, standard deviations, effect sizes, and ANOVA results of change in outcome at all time points

Changes in outcome Treatment group
BA CT MM F and P-value group** Between-group effect size d***
Mean (SD) d*
(95% CI)
Mean (SD) d*
(95% CI)
Mean (SD) d*
(95% CI)
Change in primary outcome
PROMIS pain interference
  Post-treat. minus pre-treat  − 5.6 (5.6)  − 1.00 (− 1.25, − .73)  − 5.0 (5.0)  − 1.01 (− 1.26, − .74)  − 4.5 (6.4)  − .71 (− .94, − .47) F(2,257) = .80 P = .45

BA–CT: − .11 (− .41, .19

BA–MM: − .18 (− .48, .12) MM–CT: .09 (− .21, .38)

  3 months minus pre-treat  − 5.6 (6.2)  − .90 (− 1.15, − .64)  − 4.7 (5.5)  − .86 (− 1.12, − .61)  − 3.4 (6.2)  − .54 (− .78, − .31)

F(2,240) = 2.84

P = .06

BA–CT: − .15 (− .46, .16)

BA–MM: − .36 (− .67, .05)

MM–CT: .23 (− .08, .54)

  6 months minus pre-treat  − 5.6 (7.0)  − .80 (− 1.05, − .54)  − 4.1 (6.0)  − .69 (− .93, − .45)  − 3.4 (7.4)  − .47 (− .70, − .23)

F(2,234) = 2.14

P = .12

BA–CT: − .23 (− .54, .08)

BA–MM: − .31 (− .62, .01)

MM–CT: .10 (− .21, .41)

Change in secondary outcomes
Average pain intensity
  Post-treat. minus pre-treat  − 1.3 (1.9)  − .68 (− .91, − .44)  − 1.0 (1.8)  − .55 (− .78, − .32)  − 1.2 (2.1)  − .56 (− .78, − .33)

F(2,257) = .51

P = .60

BA–CT: − .16 (− .46, .14)

BA–MM: − .05 (− .35, .24)

MM–CT: − .10 (− .39, .20)

  3 months minus pre-treat  − 1.4 (2.2)  − .62 (− .86, − .38)  − 0.9 (1.7)  − .53 (− .76, − .29)  − 0.8 (1.9)  − .43 (− .66, − .21)

F(2,242) = 2.10

P = .12

BA–CT: − .25 (− .56, .06)

BA–MM: − .28 (− .59, .03)

MM–CT: .04 (− .26, .35)

  6 months minus pre-treat  − 1.1 (2.0)  − .54 (− .77, − .30)  − 1.0 (1.9)  − .51 (− .74, − .28)  − 1.0 (2.0)  − .52 (− .75, − .28)

F(2,234) = .09

P = .91

BA–CT: − .07 (− .38, .24)

BA–MM: − .03 (− .35, .28)

MM–CT: .04 (− .35, .28)

PROMIS sleep disturbance
  Post-treat. minus pre-treat  − 4.9 (6.8)  − .71 (− .95, − .47)  − 3.5 (7.1)  − .49 (− .71, − .27)  − 1.7 (6.2)  − .27 (− .48, − .06)

F(2,257) = 4.98

P = .01

BA–CT: − .19 (− .49, .11)

BA–MM: − .49 (− .79, − .19) MM–CT: .28 (− .02, .57)

  3 months minus pre-treat  − 4.3 (8.3)  − .52 (− .75, − .29) -3.5 (6.6) -.53 (-.76, -.29) -2.1 (7.1) -.29 (-.51, -.07)

F(2,241) = 1.93

P = .15

BA—CT: -.11 (-.42, .20)

BA—MM: -.29 (-.60, .02)

MM—CT: .21 (-.10, .51)

  6 months minus pre-treat  − 4.9 (9.4)  − .52 (− .75, − .28)  − 4.0 (7.3)  − .55 (− .78, − .31)  − 3.4 (7.6)  − .44 (− .68, − .20)

F(2,234) = .68

P = .50

BA–CT: − .11 (− .41, .20)

BA–MM: − .18 (− .49, .14)

MM–CT: .09 (− .23, .40)

PROMIS physical function
  Post-treat. minus pre-treat 2.1 (3.8) .55 (.32, .77) 1.6 (3.6) .44 (.21, .66) 1.1 (3.4) .32 (.11, .54)

F(2,257) = 1.66

P = .19

BA–CT: .14 (− .16, .44)

BA–MM: .28 (− .02, .57)

MM–CT: − .14 (− .43, .16)

  3 months minus pre-treat 2.7 (4.2) .63 (.39, .87 2.0 (4.3) .47 (.24, .70) 1.2 (4.0) .29 (.07, .52)

F(2,241) = 2.61

P = .08

BA–CT: .15 (− .16, .46)

BA–MM: .36 (.05, .67)

MM–CT: − .20 (− .51, .10)

  6 months minus pre-treat 2.5 (4.8) .53 (.29, .77) 1.9 (5.6) .34 (.12, .56) 1.3 (5.2) .25 (.02, .47)

F(2,234) = 1.12

P = .33

BA–CT:.12 (− .19, .43)

BA–MM: .25 (− .07, .57)

MM–CT: − .12 (− .43, .20)

PROMIS depression
  Post-treat. minus pre-treat  − 2.6 (6.7)  − .38 (− .60, − .16)  − 3.3 (7.0)  − .46 (− .69, − .24)  − 2.6 (7.8)  − .33 (− .55, − .12)

F(2,257) = .25

P = .78

BA–CT: .10 (− .20, .40)

BA–MM: .01 (− .29, .31)

MM–CT: .09 (− .21, .38)

  3 months minus pre-treat  − 2.0 (6.4)  − .31 (− .53, − .08)  − 2.4 (6.9)  − .35 (− .57, − .12)  − 2.3 (8.2)  − .27 (− .49, − .05)

F(2,241) = .07

P = .93

BA–CT: .06 (− .25, .37)

BA–MM: .04 (− .27, .34)

MM–CT: .02 (− .29, .33)

  6 months minus pre-treat  − 1.9 (7.4)  − .25 (− .48, .03)  − 2.3 (7.7)  − .30 (− .52, − .08)  − 2.2 (9.4)  − .23 (− .46, .00)

F(2,234) = .07

P = .94

BA–CT: .06 (− .28, .37)

BA–MM: .04 (− .28, .35)

MM–CT: .02 (− .29, .33)

PROMIS anxiety
  Post-treat. minus pre-treat  − 1.5 (7.2)  − .21 (− .42, .01)  − 2.2 (7.1)  − .31 (− .53, − .10)  − 2.1 (7.9)  − .27 (− .48, − .06)

F(2,257) = .26

P = .78

BA–CT: .10 (− .20, .40)

BA–MM: .09 (− .21, .38)

MM–CT: .01 (− .28, .31)

  3 months minus pre-treat  − .4 (8.3)

 − .05

(− .27, .16)

 − 1.4 (8.6)

 − .16

(− .38, .06)

 − 2.2 (9.0)

 − .25

(− .46, − .02)

F(2,242) = .84

P = .43

BA–CT: .11 (− .20, .042)

BA–MM: .20 (− .11, .51)

MM–CT: − .09 (− .40, .21)

  6 months minus pre-treat .1 (8.9) .1 (− .22, .23)  − 1.8 (8.4)  − .22 (− .44, .00)  − 1.4 (9.4)  − .15 (− .38, .08)

F(2,234) = 1.00

P = .37

BA–CT: .22 (− .09, .53)

BA–MM: .16 (− .16, .48)

MM—CT: .05 (-.26, .36)

Positive affect
  Post-treat. minus pre-treat 1.6 (3.9) .40 (.18, .62) 1.5 (3.5) .44 (.22, .66) 1.3 (3.0) .44 (.22, .66)

F(2,257) = .16

P = .86

BA—CT: .01 (-.29, .31)

BA—MM: .08 (-.22, .38)

MM—CT: -.07 (-.37, .23)

  3 months minus pre-treat 1.0 (4.1) .23 (.01, .45) 1.4 (3.6) .39 (.16, .61) .4 (3.4) .13 (− .09, .35)

F(2,242) = 1.32

P = .27

BA–CT: − .11 (− .42, .20)

BA–MM: .14 (− .17, .44)

MM–CT: − .27 (− .58, .04)

  6 months minus pre-treat .8 (4.2) .19 (− .04, .41) .7 (3.9) .18 (− .03, .40) 1.1 (3.2) .35 (.11, .58)

F(2,234) = .24

P = .79

BA–CT: .02 (− .29, .33)

BA–MM: − .09 (− .40, .23)

MM–CT: .11 (− .20, .42)

Negative affect
  Post-treat. minus pre-treat  − 1.3 (3.3)  − .39 (− .61, -.17)  − 1.2 (3.2)  − .38 (− .60, − .16)  − .8 (4.1)  − .20 (− .41, .01)

F(2,257) = .45

P = .64

BA–CT: − .02 (− .32, .28)

BA–MM: − .13 (− .42, .17)

MM–CT: .11 (− .19, .41)

  3 months minus pre-treat  − 1.0 (3.0)  − .33 (− .55, − .10)  − .8 (3.4)  − .23 (− .45, − .01)  − .5 (3.6)  − .15 (− .36, .07)

F(2,242) = .40

P = .68

BA–CT: − .07 (− .38, .24)

BA–MM: − .14 (− .45, .17)

MM–CT: .07 (− .24, .38)

  6 months minus pre-treat  − 1.0 (3.9)  − .26 (− .49, − .04)  − .7 (3.8)  − .20 (− .41, .02)  − .5 (4.2)  − .11 (− .34, .12)

F(2,234) = .38

P = .68

BA–CT: − .07 (− .38, .24)

BA–MM: − .14 (− .45, .18)

MM–CT: .07 (− 24, .38)

*Effect size (Cohen’s d) within an intervention group for a specific follow-up time point and 95% confidence interval calculated via macro effectsize in R for one sample

**F statistics and P-value for intervention from ANOVA with change in score as the response variable and intervention as factor

***Effect size (Cohen’s d) between intervention groups for a specific follow-up time point, and 95% Confidence Interval calculated via macro effectsize in R. Effect sizes shown are for the mean of first intervention minus mean of second intervention, using pooled standard deviation