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. 2024 Apr 12;22:156. doi: 10.1186/s12916-024-03383-2

Table 3.

Medication and utilization of healthcare

Outcomes Treatment group χ2(df),
P-value
group**
Between-group difference in proportion of decreased medication/healthcare usage***
BA CT MM
N (%) Proportion (95% CI) N (%) Proportion (95% CI) N (%) Proportion (95% CI)
Change in average daily morphine milligram equivalent (MME) in past week
 From pre- to post-treatment
  No prescription at pre- or post 58 (65.2) .65 (.55, .75) 58 (68.2) .68 (.58, .78) 61 (70.1) .70 (.60, .79)

χ2 (6) = 10.33

P = .11

BA–CT: .06 (− .04, .17)

BA–MM: − .01 (− .13, .10)

MM–CT: .08 (− .03, .18)

  Increase in dose from pre- to post 6 (6.7) .07 (.02, .13) 9 (10.6) .11 (.05, .18) 10 (11.5) .12 (.06, .19)
  Decrease in dose from pre- to post 12 (13.5) .14 (.08, .22) 6 (7.1) .07 (.03, .15) 13 (14.9) .15 (.09, .24)
  No change in dose from pre- to post 13 (14.6) .15 (.08, .22) 12 (14.1) .15 (.07, .22) 3 (3.4) .04 (.01, .08)
 From pre- to 3 months
  No prescription at pre- or 3 months 49 (62.0) .62 (.51, .72) 53 (65.4) .65 (.55, .75) 53 (67.9) .68 (.57, .78)

χ2 (6) = 4.55

P = .60

BA–CT: .08 (− .04, .20)

BA–MM: .05 (− .08, .17)

MM–CT: .03 (− .08, .14)

  Increase in dose from pre- to 3 months 9 (11.4) .12 (.05, .19) 13 (16.0) .16 (.09, .25) 12 (15.4) .16 (.08, .23)
  Decrease in dose from pre- to 3 months 14 (17.7) .18 (.11, .28) 8 (9.9) .10 (.05, .19) 10 (12.8) .13 (.07, .22)
  No change in dose from pre- to 3 months 7 (8.9) .09 (.04, .16) 7 (8.6) .09 (.03, .15) 3 (3.8) .04 (.01, .09)
 From pre- to 6 months
  No prescription at pre- or 6 months 51 (63.7) .64 (.53, .74) 50 (64.1) .64 (.53, .74) 48 (66.7) .66 (.56, .77)

χ2 (6) = 6.33

P = .39

BA–CT: − .003 (− .11, .10)

BA–MM: − .01 (− .13, .11)

MM–CT: .01 (− .11, .13)

  Increase in dose from pre- to 6 months 10 (12.5) .13 (.06, .20) 11 (14.1) .15 (.07, .22) 13 (18.1) .18 (.10, .27)
  Decrease in dose from pre- to 6 months 10 (12.5) .12 (.07, .22) 10 (12.8) .13 (.07, .22) 10 (13.9) .14 (.08, .24)
  No change in dose from pre- to 6 months 9 (11.3) .12 (.05, .19) 7 (9.0) .09 (.04,.16) 1 (1.4) .02 (.00, .05)
Change in number of healthcare visits in past month
 From pre- to post-treatment
  Decreased number from pre-treatment 39 (45.3) .45 (.35, .56) 43 (50.0) .50 (.40, .60) 38 (43.2) .43 (.33, .54)

χ2 (4) = 2.65

P = .62

BA–CT: − .05 (− .21, .11)

BA–MM: .02 (− .14, .18)

MM–CT: − .07 (− .23, .09)

  Same number as pre-treatment 24 (27.9) .28 (.19, .38) 16 (18.6) .19 (.11, .27) 21 (23.9) .24 (.16, .33)
  Increased number from pre-treatment 23 (26.7) .27 (.18, .36) 27 (31.4) .32 (.22,.41) 29 (33.0) .33 (.24, .43)
 From pre-treatment to 3 months
  Decreased number from pre-treatment 35 (44.3) .44 (.34, .55) 28 (34.6) .35 (.25, .45) 30 (36.6) .37 (.30, .47)

χ2 (4) = 2.91

P = .57

BA–CT: .10 (− .07, .26)

BA–MM: .08 (− .09, .24)

MM–CT: .02 (− .14, .18)

  Same number as pre-treatment 21 (26.6) .27 (.17, .37) 20 (24.7) .25 (.16, .34) 20 (24.4) .25 (.16, .34)
  Increased number from pre-treatment 23 (29.1) .29 (.20, .39) 33 (40.7) .41 (.30, .51) 32 (39.0) .39 (.29, .50)
 From pre-treatment to 6 months
  Decreased number from pre-treatment 32 (41.0) .41 (.31, .52) 39 (47.0) .47 (.37, .58) 32 (42.7) .43 (.32, .54)

χ2 (4) = 1.66

P = .80

BA–CT: − .06 (− .23, .11)

BA–MM: − .02 (− .19, .15)

MM–CT: − .04 (− .21, .12)

  Same number as pre-treatment 17 (21.8) .22 (.13, .31) 19 (22.9) .23 (.14, .32) 14 (18.7) .19 (.11, .28)
  Increased number from pre-treatment 29 (37.2) .37 (.27, .48) 25 (30.1) .30 (.21, .40) 29 (38.7) .39 (.28, .50)

*Proportion of individuals who decreased medication dose or healthcare utilization and 95% confidence interval as estimated by Jeffrey’s method (Bayesian approach)

**χ2 statistics (degrees of freedom) and P-value from Pearson chi-square test of homogeneity (equality of distributions among categories) comparing proportion of decrease in medication or decrease in healthcare usage

***Difference in proportion of decrease in medication or decrease in healthcare usage (first treatment minus second treatment) and 95% confidence interval