FIG. 5.

(A) Mice were passively immunized with 200 or 2,000 μg of human anti-HSV IgG, or saline (0 μg IgG) as a control, and then infected 16 h later with FcγR⁺ virus NS or rNS-gE₃₃₉ or FcγR⁻ virus NS-gE₃₃₉. Ten mice were evaluated at each data point. Disease scores in saline controls were set as 100%, and as shown in Fig. 4A, these scores were similar for all three viruses. Percent disease scores at 200 or 2,000 μg of human anti-HSV IgG were calculated as [mean (± SEM) disease score in animals receiving human anti-HSV IgG/mean disease score in saline-treated animals] × 100. (B) Mice were passively immunized with 200 or 2,000 μg of nonimmune human IgG, or saline (0 μg of IgG) as a control. Five mice were included at each data point. Percent disease scores were calculated as [mean (± SEM) disease score in animals receiving nonimmune IgG/mean disease score in saline-treated animals] × 100. (C) Mice were passively immunized with 200 or 2,000 μg of murine anti-HSV IgG, or saline (0 μg of IgG), as a control. Five mice were included at each data point. Percent disease scores were calculated as [mean (± SEM) disease score in animals receiving murine anti-HSV IgG/mean disease score in saline-treated animals] × 100.