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. Author manuscript; available in PMC: 2024 Apr 13.
Published in final edited form as: Annu Rev Nutr. 2023 Aug 21;43:385–407. doi: 10.1146/annurev-nutr-061021-025153

Table 2.

Current existing definitions of Dietary Reference Intake recommendationsa

Recommendation Definition
Acceptable Macronutrient Distribution Range (AMDR) The percentage of total energy intake, expressed as a percentage of total energy, that is associated with a reduced risk of chronic disease and can provide adequate amounts of essential nutrients; intakes that fall above or below the range increase the potential for elevated risk of chronic disease or risk of inadequate consumption of essential nutrients
Estimated Energy Requirement (EER) The average dietary energy intake that is predicted to maintain energy balance for a defined age, sex, weight, height, and level of physical activity, consistent with maintaining health
Estimated Average Requirement (EAR) The average daily nutrient intake that is estimated to meet the requirement of half the healthy individuals in a particular life stage and gender group
Recommended Dietary Allowance (RDA) The average daily dietary nutrient intake that is sufficient to meet the nutrient requirements of nearly all (97% to 98%) healthy individuals in a particular life stage and gender group
Adequate Intake (AI) The recommended average daily intake level based on observed or experimentally determined approximations or estimates of nutrient intake by a group (or groups) of apparently healthy people that are assumed to be adequate; an AI is used when an EAR/RDA cannot be determined
Tolerable Upper Intake Level (UL) The highest average daily nutrient intake level that is likely to pose no risk of adverse health effects to almost all individuals in the general population; as intake increases above the UL, the risk of adverse effects may increase
Chronic Disease Risk Reduction (CDRR) The lowest level of intake for which there is sufficient strength of evidence to characterize a chronic disease risk reduction
a

These definitions represent those of the Food and Nutrition Board of the National Academy of Medicine (38).