TABLE 5.
The frequencies of micronucleated reticulocytes in the peripheral blood of male ICR mice treated with Symbiota® (MS‐20).
| Group | Name | Dose (ml/kg) | Individual animal data (MN/1000 RETs) | Mean ± SD (MN/1000 RETs) | ||||
|---|---|---|---|---|---|---|---|---|
| 1 | Negative control a | 0 | 0.5 | 0.5 | 1 | 0.5 | 0 | 0.5 ± 0.4 |
| 2 | Low | 5 | 1.5 | 1 | 0.5 | 0.5 | 1.5 | 1.0 ± 0.5 |
| 3 | Middle | 10 | 0 | 1.5 | 2 | 0.5 | 0 | 0.8 ± 0.9 |
| 4 | High | 20 | 0.5 | 0 | 1.5 | 2.5 | 1.5 | 1.4 ± 0.9 |
| 5 | Positive control b | – | 36 | 22.5 | 33 | 28.5 | 20 | 28.0 ± 6.8 |
a
Negative control: Injection grade water.
b
Positive control: 1.0 mg/kg mitomycin C.