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. 2024 Jan 24;31(4):562–573. doi: 10.1038/s41417-024-00731-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A–F The migration and invasion abilities were analyzed in RanGAP1 knockdown and overexpressed CRC cells. G Representative mice injected with RanGAP1 knockdown DLD1 cells and control cells were measured for CRC lung metastases. H, I Lung from nude mice were obtained and analyzed. J–L The HE-staining detected the expression of the metastatic nodules of lung in the different groups.