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. 2024 Jan 24;31(4):562–573. doi: 10.1038/s41417-024-00731-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The volcano plot of differential mRNA expression in RanGAP1 silenced DLD1 and control group ( | log2(fold change) |>1 and p value < 0.05). B KEGG enrichment analysis of different genes in RanGAP1 knockdown cells and control cells. C, D Expression levels of proteins associated with the MAPK signaling pathway were evaluated in CRC cells transfected stably with the shRanGAP1, shNC+Control, shMETTL3+Control, shMETTL3+RanGAP1, shYTHDF1+Control and shYTHDF1 + RanGAP1.