Table 2.
Classification of acute myeloid leukemia with myelodysplasia-related changes
| WHO2016 | WHO2022 | ICC |
|---|---|---|
| Complex karyotype (≥ 3 abnormalities) | Cytogenetic abnormalities | Cytogenetic abnormalities |
| Unbalanced abnormalities | Complex karyotype (≥ 3 abnormalities) | Complex karyotype (≥ 3 abnormalities) |
| del(5q) or t(5q) | 5q deletion or loss of 5q | del(5q)/t(5q)/add(5q) |
| Loss of chromosome 7 or del(7q) | monosomy 7, 7q deletion, or loss of 7q | -7/del(7q) |
| Loss of chromosome 13 or del(13q) | 11q deletion | +8 |
| del(11q) | 12p deletion or loss of 12p | del(12p)/t(12p)/add(11p) |
| del(12p) or t(12p) | Monosomy 13 or 13q deletion | i(17q), -17/add(17p) or del(17p) |
| isochromosome 17q or t(17p) | 17p deletion or loss of 17p, isochromosome 17q | del(20q) |
| idic(X)(q13) | idic(X)(q13) | idci(X)(q13) |
| Balanced abnormalities | Defining somatic mutations | Gene mutations |
| t(11;16)(q23.3;p13.3) | ASXL1 | ASXL1 |
| t(3;21)(q26.2;q22.1) | BCOR | BCOR |
| t(1;3)(p36.3;q21.2) | EZH2 | EZH2 |
| t(2;11)(p21;p23.3) | SF3B1 | RUNX1 |
| t(5;12)(q32;p13.2) | SRSF2 | SF3B1 |
| t(5;7)(q32;q11.2) | STAG2 | SRSF2 |
| t(5;17)(q32;p13.2) | U2AF1 | STAG2 |
| t(5;10)(q32;q21) | ZRSR2 | U2AF1 |
| t(3;5)(q25.3;q35.1) | ZRSR2 |