Figure 11.

Mpro inhibition assay. (A) BZG1, BZG2, and BZG3 inhibition activity was measured against the control condition (vehicle). The percentage of inhibition was calculated assuming that the Mpro cleavage rate at the control condition was 100%. The compound contraction in which maximum inhibition was achieved was set as the concentration of maximum inhibition. IC₅₀ ± SEM values were obtained based on the reduction of Mpro proteolytic activity. (B) Lineweaver–Burk plot of Mpro inhibition by BZG2. All experiments were performed as four independent experiments.