Figure 4.

Gamma Knife and LINAC treatment modalities induce differential genomic signatures and DNA damage across matched primary tumor types

(A) Schematic depicting comparison between GK and LINAC treated samples with representative images for dose contouring on individual patients.

(B) Chromosome visualization of mutations between GK and LINAC treated samples across central and peripheral biopsy locations.

(C) Quantification of total variants detected among peripheral samples between GK and LINAC SRS delivery.

(D) Volcano plot of DESeq2 determined differentially expressed genes between GK and LINAC treated samples.

(E) GSEA enrichment of DE genes when compared across GK and LINAC dosing modality.

(F) Visualization of enriched CTA genes using Human Protein Atlas data. Error bars indicate SD. Differential expression analysis was done within DESeq2 using adjusted p value <0.05 ∗p < 0.05.