Table 2.
Top 10 canonical pathways.
| Ingenuity canonical pathways | -log(p-value) | zScore | Molecules | Physiological mechanisms in WS meat |
|---|---|---|---|---|
| BAG2 signaling pathway | 3.93 | CASP3, HSPA4, HSPA9, MAPK14, MAPKAPK2, MAPT | Co-chaperone with HSP70/80 & necrosis (Qin et al., 2016) | |
| Glycogen degradation III | 3.85 | GAA, MTAP, PGM5 | Decreased carbohydrate metabolisms (Kuttappan et al., 2017) | |
| Isoleucine degradation I | 3.34 | ACAA2, BCAT1, DLD | Decreased branched chain aa catabolism (Boerboom et al., 2018; Holecek, 2018) | |
| Aldosterone signaling in epithelial cells | 3.20 | CRYAB, DNAJB4, HSPA4, HSPA9, HSPD1, HSPE1, HSPH1 | Blood pressure control/ hypoxia (Ayansola et al., 2021; Xanthakis and Vasan, 2013) | |
| Valine degradation I | 3.11 | BCAT1, DLD, HIBADH | Decreased branched chain aa catabolism (Holecek, 2018) | |
| Protein ubiquitination pathway | 3.00 | CRYAB, DNAJB4, HSPA4, HSPA9, HSPD1, HSPE1, HSPH1, THOP1, UBR1 | Protein degradation (Boerboom et al., 2018) | |
| HIF1α signaling | 2.94 | 1.9 | CAMK2D, CAMK2G, EIF4E, EIF4EBP1, HSPA4, HSPA9, VIM | Hypoxia (Malila et al., 2019) |
| Mitochondrial dysfunction | 2.53 | 0.3 | CAMK2D, CAMK2G, CASP3, CLIC2, COX17, DLD, GPX4, MAPT, SOD1 | Mitochondrial Dysfunction (Prisco et al., 2021) |
| Glycogen degradation II | 2.40 | MTAP, PGM5 | Decreased carbohydrate metabolism (Kuttappan et al., 2017) | |
| Natural killer cell signaling | 2.36 | COL1A1, COL1A2, HSPA4, HSPA9, IL18, MAPK14 | Immune cell infiltration (Prisco et al., 2021) |