Figure 5.

Ligands and receptor protein expression in NCSCs and organoids

(A–C) Heatmaps show the expression of growth factor ligands (A), ECM ligands (B), and receptors (C) in stem cells, NCSs, NCSCs and craniofacial cartilage organoids from mass spectrometry data. Data are expressed as row z-scores (see legend in C); black represents missing data.

(D and E) Selected non-ECM (D) and ECM (E) ligand-receptor pairs derived from protein data. Node size and color is proportional to the maximum row Z score (inset). Edges are from connectome.²⁷ Node border and shape and edge colors are defined in Figure S7C.