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. 2024 Mar 18;45(2):314–328. doi: 10.24272/j.issn.2095-8137.2023.222

Table 2. Functions of REGs with the most significant correlations (P<0.01).

Model Group Term Description Gene symbol
Branch models LBC GO:0090630 Activation of GTPase activity tbc1d7, arhgef15b, arhgap29a, bcl2l1, pcsk1nl
GO:0030684 Pre-ribosome pwp2h, nol6, riok3
GO:0045861 Negative regulation of proteolysis bcl2l1, pcsk1nl, bag6l, topbp1, cul4b
GO:0048592 Tissue morphogenesis tbx2b, aldh1a2, top2b, npc1, ezrb, pfn1, bag6l
R-DRE-73894 DNA Repair topbp1, cul4b, parp1
GO:0005319 Lipid transporter activity osbpl2b, npc1, slco2b1
R-DRE-2990846 SUMOylation uba2, parp1, top2b
GO:0080135 Regulation of cellular response to stress topbp1, otub1b, il6st
GO:0008514 Organic anion transmembrane transporter activity slc35b4, slc38a2, slco2b1
GO:0043632 Modification-dependent macromolecule catabolic process fbxl5, cul4b, bag6l, sgpl1, ufc1, cand2, uba2, otub1b, usp3, smg1
GO:0001501 Skeletal system development aldh1a2, b4galt7, npc1, crispld2
SBC GO:0005975 Carbohydrate metabolic process insra, amdhd2, hexa, neu1, kl, galk2, pargl, dpydb, lipeb, pafah1b2
dre04512 ECM-receptor interaction thbs1b, hspg2, col6a2, itgav, dync1h1, tfr1b, stx12l, rock2a, kdrl
GO:1901565 Organonitrogen compound catabolic process rock2a, lnpep, amdhd2, dpydb, uba1, hexa, ube3b, neu1, uba7, usp18
GO:1901699 Cellular response to nitrogen compound nr4a1, sesn1, chrne, kl, esr2b, cnn2
GO:0106310 Protein serine kinase activity rock2a, ripk2, sik1, dapk1, insra, nrbp1, pkn2a, stk17al, kdrl
GO:0019838 Growth factor binding igfbp1a, kl, kdrl
GO:0008238 Exopeptidase activity lnpep, scpep1, prss16, f7i, cfi, pgpep1, usp18
GO:0080134 Regulation of response to stress f7i, uba1, sesn1, pros1, pargl, gpr183a
GO:0098802 Plasma membrane signaling receptor complex insra, chrne, itgav, kdrl
WP467 mRNA processing hnrnpaba, xrn2, snrpa1
GO:0000904 Cell morphogenesis involved in differentiation unk, uba1, pls3, gpr183a, als2a, col6a2
GO:0005769 Early endosome tfa, tmem184a, als2a
GO:1904888 Cranial skeletal system development pls3, hspg2, pkn2a, usp18
GO:0048514 Blood vessel morphogenesis cfi, hspg2, kdrl, itgav, tgfbr3
GO:0005654 Nucleoplasm hnrnpaba, chtopa, rcor3, pnisr, ibtk, krt8
Branch-site models LBC GO:0045576 Mast cell activation ndrg1a
SBC GO:0003308 Negative regulation of Wnt signaling pathway involved in heart development jup