Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 10;25(2):541–558. doi: 10.1093/biostatistics/kxad007

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

PMC Copyright notice

Fig. 3. — Applying SICERS to clinical data (a)–(c) and replication data (d)–(f). (a) A heatmap of of the first data set (); hotter pixels indicate more differential edges between cases and controls, and there is no apparent topological pattern for these hot edges. (b) We then perform SICERS in and find a significant subnetwork [the bold square, which is magnified in (c)]. (c) The enlarged disease-relevant subnetwork in with region names. (d) A heatmap of of the second data set (). (e) The disease-relevant subnetwork was detected by using alone. (f) The enlarged network in with region names. To save space here, versions of the enlarged plots (c) and (f) with more-readable axis labels are included in the supplementary material available at Biostatistics online.

Inline graphic — Applying SICERS to clinical data (a)–(c) and replication data (d)–(f). (a) A heatmap of of the first data set (); hotter pixels indicate more differential edges between cases and controls, and there is no apparent topological pattern for these hot edges. (b) We then perform SICERS in and find a significant subnetwork [the bold square, which is magnified in (c)]. (c) The enlarged disease-relevant subnetwork in with region names. (d) A heatmap of of the second data set (). (e) The disease-relevant subnetwork was detected by using alone. (f) The enlarged network in with region names. To save space here, versions of the enlarged plots (c) and (f) with more-readable axis labels are included in the supplementary material available at Biostatistics online.