Effects of mammalian cyclooxygenase inhibitors on (A) ovarian COX activity (N=47), and, (B) circulating prostaglandin-F2α (N=64) in female fathead minnows (two-way ANOVA followed by the Dunnett’s post-hoc test). Specific treatments significantly different (Dunnett’s post-hoc test, p < 0.05) from their respective controls (i.e., ovulated treated versus ovulated controls, and non-ovulated treated versus non-ovulated controls) are labeled with an asterisk (*).