Table 1.
Overview of enrichment of predefined sets of genes associated with fish reproductive function - gene set enrichment analysis (GSEA) for microarray data.
| Gene Set (total number of genes in each gene set) | IN | IB | CX |
|---|---|---|---|
| Gonad All (78) | C | ||
| Gonad All With Neighbors (227) | C | ||
| Gonad Steroid Biosynthesis (11) | C | ||
| Gonad Prostaglandin-Related (10) | IN | ||
| Gonad Oocyte Maturation (21) | |||
| Gonad Oocyte Growth (10) | |||
| Gonad Cholesterol Synthesis (12) | CX | ||
| Gonad Minus Cholesterol Synthesis (67) | C | ||
| Gonad Ccnb1 Plus Neighbors (106) | |||
| Gonad Acvrl1 Plus Neighbors (12) | C | C | |
| Gonad Oocyte Maturation Plus Neighbors (143) | |||
| Gonad Oocyte Growth Plus Neighbors (113) | |||
| Gonad Cholesterol Uptake Plus Neighbors (15) | C | ||
| Gonad Steroid Biosynthesis Plus Neighbors (12) | C | ||
| Gonad Ccnb1 Zp3 Plus Non-Redundant Neighbors (118) | CX | ||
| Liver All (38) | C | ||
| Liver Cholesterol Biosynthesis (13) | |||
| Liver Steroid Metabolism (17) | |||
| Pituitary All (26) | |||
| Brain All (19) | |||
| Hypothalamic-Pituitary-Gonadal-Hepatic All (138) | C |
Gray shading indicates significant enrichment in the control group compared to the treated; black shading indicates significant enrichment in the treated group relative to control; lack of shading indicates no significant enrichment (false discovery rate < 25% was considered statistically significant). C - Control, IN - Indomethacin, IB - Ibuprofen, CX- Celecoxib.