Figure 5.

Representative images of HCC827 tumor-bearing mice treated with 1 nmol CNDC in the presence or absence of competing unlabeled Centyrin. Mice were injected via tail vein with 1 nmol CNDC in the presence or absence of a 100-fold excess of 83v2Cys to block all vacant receptor binding sites and fluorescence images were acquired over the ensuing 4 h. Organs and tissues were resected after whole animal imaging at 4 h and are labeled as follows: 1) tumor, 2) heart, 3) lungs, 4) liver, 5) spleen, 6) kidneys, 7) stomach, 8) small intestine, 9) large intestine, 10) skin, 11) muscle.