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Synthesis of the Centyrin near-infrared dye labeling reagenta
aReagents and conditions: (a) 3-(4-Hydroxyphenyl)propionic acid, KOH (2 equiv), DMSO, 60°C, 60 min (b) (i) HATU, DIPEA, DMSO, r.t. 25 min, (ii) N-(2-aminoethyl)malemide trifluoroacetate salt (2 equiv) stir overnight, (iii) isopropanol, centrifugation; (c) PBS and gentle mixing for 60 min
