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. 2023 Dec 17;30(4):e14524. doi: 10.1111/cns.14524

FIGURE 6.

FIGURE 6

VPA inhibited ferroptosis via HDAC2‐H4K12ac axis. (A‐C) Western blotting and semi‐quantifications for ac‐H3K14 and ac‐H4K12 protein in different groups (N = 5) ns = no significant, **p < 0.01; *p < 0.001. (D) ChIP of samples showed specificity of DNA binding for HDAC2 and HDAC1. (E‐F)Changes in histone acetylation in GPX4, SLC7A11, and Nrf2 promoter regions in different groups, sonicated chromatin was IP with anti‐AcH3 or anti‐AcH4 and quantified with qRT‐PCR. ns = no significant *p < 0.05; **p < 0.01; *p < 0.001.