Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Ketamine and its metabolites produce anesthetic and antidepressant effects by acting on NMDARs. The inhibition of NMDARs by ketamine and its metabolites affects synaptic/extrasynaptic NMDAR‐mediated functions, which might disrupt the balance of excitation and inhibition, thereby generating antidepressant and anesthetic effects.
