Fig. 5.

Astragaloside IV-PESV could affect the composition of the gut microbiota of PCa mice. A. PCa nude mice and tumor plots. B. Body weight. C. The data of four-week tumor volume. D. Tumor mass. E. HE staining plots of tumor tissues. F. IHC was used to analyze the Ki67 positive rate of tumor tissues. G. The mRNA level of RAGE in tumor tissues. H.The protein level of RAGE in tumor tissues. I. The protein level of NF-κB, TNF-α and IL-6 in tumor tissues. Western blot was used to detect the protein expression levels of NF-κB, TNF-α and IL-6 in tumor tissues. *, P < 0.05 compared with the Control group