Table 2.

Literature review

Case (age/sex)	Pathology	Immunofluorescence	IgG	anti-GBM antibodies	Electron microcopy
31/M	Proliferative basement membranes, focal crescents, and mesangial proliferation.	IgG (+); IgA (+); IgM (+); C3 (-); C1q (-); Fib (-); ALB (-); kappa (+); and lambda (+).	linear deposition	Negative	No electron-dense deposits and presence of foot process fusion.
57/F [20]	Mesangial proliferation, and focal crescents.	IgG (+); IgA (+); IgM (-); C3 (+); C1q (-); kappa (+); and lambda (+).	linear deposition	Negative	No electron-dense deposits and extensive FPE.
53/M [21]	Proliferative basement membranes, focal crescents, and segmental nodular glomerulosclerosis	IgG1 (+); IgG4 (+).	linear deposition	Negative	Fibrillar deposition.
74/M [22]	Mesangial proliferation, no crescents, and thinning basement membranes	IgG1 (+);IgG4 (+);IgG2 (+); kappa (+); and lambda (+).	linear deposition	Negative	Accumulation of flocculent debris.
43/F [23]	Focal crescents and endocapillary hypercellularity	IgG (+); IgA (-); IgM (-); C3 (-); C4 (-); C1q (-); IgG1 (+);IgG4 (+); IgG2 (-);IgG3 (-); kappa (+); and lambda (+).	linear deposition	Negative	Some FPE
13/F [24]	Mesangial proliferation, focal crescents, some globally or segmentally sclerosed glomeruli	IgG (+); IgA (+); IgM (-); C3 (+);C1q (-); IgG1 (+);IgG4 (+);kappa (+); and lambda (+).	linear deposition	Negative	NA
4/F [25]	Subtle segmental scars, segmental endocapillary hypercellularity, and cellular crescent	IgG (+);IgA (-); IgM (-); C3 (-); C1q (-).	linear deposition	Negative	No electron-dense deposits
30/M [26]	Normal	IgG (+);C3 (+);kappa (+); and lambda (+).	linear deposition	Negative	NA
58/M [27]	Focal crescents and proliferative, and sclerosing glomerulonephritis	IgG (+); IgA (+); kappa (+); and lambda (+).	linear deposition	Negative	NA
79/M [28]	NA	IgG (+); IgA (+); C3 (+); and lambda (+); fibrinogen (+).	linear deposition	Negative	NA
48/F [11]	Some globally sclerotic glomeruli, cellular and fibric crescents, Bowman’s capsules and segmental sclerotic glomeruli, tubular atrophy accompanied by interstitial fibrosis, interstitial infiltration of lymphocytes, monocytes, and plasmocytes	IgG (+)	linear deposition	Negative	No electron-dense deposits and presence of foot process fusion.
37/M [29]	diffuse proliferation in the glomeruli, with increased mesangial proliferation; crescents	IgG (+);C3 (+).	linear deposition	Negative	No electron-dense deposits.
64/M [30]	Necrotizing glomerulonephritis, cellular crescent, and diffuse segmental endocapillary proliferation.	IgG1-κ (+).	linear deposition	Negative	NA
69/M [31]	Mesangial proliferation, diffuse endocapillary hypercellularity, mesangiolysis, and extracapillary proliferation	IgG (+); IgG1 (+); IgG2 (+);IgG3 (-); IgG4 (-);	linear deposition	Negative	No electron-dense deposits, diffuse foot process effacement and subendothelial space widening
70/M [32]	Cellular crescents and necrotic lesions	IgG (+);IgM (-); C3 (-);kappa (+); and lambda (+); fibrinogen (+).	linear deposition	Negative	Proliferative basement membranes
46/F [12]	Cellular crescents and fibrinoid necrosis.	IgG (+); IgG1 (+); IgG2 (+);IgG3 (-); IgG4 (+).	linear deposition	Negative	Normal
53/F [33]	Interstitial fibrosis, tubular atrophy, moderate arteriosclerosis, and moderate arteriolar hyalinosis of moderate chronicity	IgG1-kappa (+); IgG1 (+); IgG2 (+);IgG3 (-); IgG4 (+).	linear deposition	Negative	No electron-dense deposits and extensive FPE
24/M [34]	Cellular crescents and mesangial proliferation,	IgG (+); IgA (+); IgM (-); C3 (-); C1q (-);IgG2 (+); IgG4 (+).	linear deposition	Negative	No electron-dense deposits
33/M [35]	Mesangial proliferation, focal interstitial fibrosis, and tubular atrophy	IgG (+);C3 (+); C4d (-).	linear deposition	Negative	NA
37/M [36]	Cellular crescents	IgG (-); IgA (+).	linear IgA deposition	Negative	NA

+: positive; -: negative. FPE: podocyte foot process effacement. NA: not available